I am right-handed, but with having had two kids and having to hold them all the time, I had to get used to using either hand to move the mouse or using the touch pad.

Although I’m ambidextrous anyway, I still wasn’t used to using my left hand to move the mouse, so I still had to learn. Surprisingly it wasn’t all that hard and it actually feels more comfortable than using my right hand. Obviously, this will not work very well if you have a mouse made to use with the right hand.

I just read about why you should mouse with the other hand over at LifeHacker. Check it out and maybe you’ll start using your left hand.